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All rights reserved Material in this book originally published in “Nucleic Acid Structure and Recognition”, by Stephen Neidle (Oxford University Press, 2002) No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means electronic, mechanical, photocopying, recording or otherwise without the prior written permission of the publisher Permissions may be sought directly from Elsevier’s Science & Technology Rights Department in Oxford, UK: phone (+44) (0) 1865 843830 fax (+44) (0) 1865 853333 email. TOKYO Academic Press is an imprint of ElsevierĪcademic Press is an imprint of Elsevier 84 Theobald’s Road, London WC1X 8RR, UK Radarweg 29, PO Box 211, 1000 AE Amsterdam, The Netherlands Linacre House, Jordan Hill, Oxford OX2 8DP, UK 30 Corporate Drive, Suite 400, Burlington, MA 01803, USA 525 B Street, Suite 1900, San Diego, CA 92101-4495, USA First edition 2008 Copyright © 2008 Elsevier Inc.Torrey Pines Road, La Jolla, CA, 92037, USA.Principles of Nucleic Acid Structure Stephen Neidle The School of Pharmacy University of London, London, UK Despite the large rotation of the branches, both junction structures exhibit an antiparallel arrangement of the continuous strands and opposite polarity of the crossover strands.ĭepartment of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. The stacked-X conformation maximizes base-stacking but causes unfavorable repulsion between phosphate groups, whereas the 135 degrees -rotated "crossed" conformation minimizes electrostatic clashes at the expense of reduced base-stacking. Comparison of the two conformers provides insight into the factors contributing to the flexibility of four-way junctions. The structure of the junction differs substantially from the "stacked-X" conformation observed previously, due to a 135 degrees rotation of the branches. Diversity, Equity, Inclusion, and AccessĪ crystal structure of a 108 nucleotide RNA-DNA complex containing a four-way junction was solved at 3.1 A resolution.Citation, Usage, Privacy Policies, Logo.Biologically Interesting Molecule Reference Dictionary (BIRD).